Israel hits Hamas buildings, shoots down Tel Aviv-bound rocket

GAZA/JERUSALEM (Reuters) – Israeli aircraft bombed Hamas government buildings in Gaza, and the “Iron Dome” defense system shot down a Tel Aviv-bound rocket on Saturday as Israel geared up for a possible ground invasion.

Hamas, the Palestinian Islamist group that runs the Gaza Strip, said Israeli missiles wrecked the office building of Prime Minister Ismail Haniyeh – where he had met on Friday with the Egyptian prime minister – and struck a police headquarters.

Along the Tel Aviv beachfront, volleyball games came to an abrupt halt and people crouched as sirens sounded. Two interceptor rockets streaked into the sky. A flash and an explosion followed as Iron Dome, deployed only hours earlier near the city, destroyed the incoming projectile in mid-air.

With Israeli tanks and artillery positioned along the Gaza border and no end in sight to hostilities now in their fourth day, Tunisia’s foreign minister travelled to the enclave in a show of Arab solidarity.

In Cairo, a presidential source said Egyptian President Mohamed Mursi would hold four-way talks with the Qatari emir, the prime minister of Turkey and Hamas chief Khaled Meshaal in the Egyptian capital on Saturday to discuss the Gaza crisis.

Egypt has been working to reinstate calm between Israel and Hamas after an informal ceasefire brokered by Cairo unraveled over the past few weeks. Meshaal, who lives in exile, has already held a round of talks with Egyptian security officials.

Officials in Gaza said 43 Palestinians, nearly half of them civilians including eight children, had been killed since Israel began its air strikes. Three Israeli civilians were killed by a rocket on Thursday.

Israel unleashed its massive air campaign on Wednesday with the declared goal of deterring Hamas from launching rockets that have plagued its southern communities for years.

The Israeli army said it had zeroed in on a number of government buildings during the night, including Haniyeh’s office, the Hamas Interior Ministry and a police compound.

Taher al-Nono, a spokesman for the Hamas government, held a news conference near the rubble of the prime minister’s office and pledged: “We will declare victory from here.”

Hamas‘s armed wing claimed responsibility for Saturday’s rocket attack on Tel Aviv, the third against the city since Wednesday. It said it fired an Iranian-designed Fajr-5 at the coastal metropolis, some 70 km (43 miles) north of Gaza.

“Well that wasn’t such a big deal,” said one woman, who had watched the interception while clinging for protection to the trunk of a baby palm tree on a traffic island.

In the Israeli Mediterranean port of Ashdod, a rocket ripped into several balconies. Police said five people were hurt.

Among those killed in airstrikes on Gaza on Saturday were at least four suspected militants riding on motorcycles.

Israel’s operation has drawn Western support for what U.S. and European leaders have called Israel’s right to self-defense, along with appeals to avoid civilian casualties.

Hamas, shunned by the West over its refusal to recognize Israel, says its cross-border attacks have come in response to Israeli strikes against Palestinian fighters in Gaza.

RESERVIST CALL-UP

At a late night session on Friday, Israeli cabinet ministers decided to more than double the current reserve troop quota set for the Gaza offensive to 75,000, political sources said, in a signal Israel was edging closer to an invasion.

Around 16,000 reservists have already been called up.

Asked by reporters whether a ground operation was possible, Major-General Tal Russo, commander of the Israeli forces on the Gaza frontier, said: “Definitely.”

“We have a plan … it will take time. We need to have patience. It won’t be a day or two,” he added.

A possible move into the densely populated Gaza Strip and the risk of major casualties it brings would be a significant gamble for Prime Minister Benjamin Netanyahu, favorite to win a January national election.

Hamas fighters are no match for the Israeli military. The last Gaza war, involving a three-week long Israeli air blitz and ground invasion over the New Year period of 2008-09, killed over 1,400 Palestinians, mostly civilians. Thirteen Israelis died.

But the Gaza conflagration has stirred the pot of a Middle East already boiling from two years of Arab revolution and a civil war in Syria that threatens to spread beyond its borders.

“Israel should understand that many things have changed and that lots of water has run in the Arab river,” Tunisian Foreign Minister Rafik Abdesslem said as he surveyed the wreckage from a bomb-blast site in central Gaza.

One major change has been the election of an Islamist government in Cairo that is allied with Hamas, potentially narrowing Israel’s manoeuvering room in confronting the Palestinian group. Israel and Egypt made peace in 1979.

“DE-ESCALATION”

Netanyahu spoke late on Friday with U.S. President Barack Obama for the second time since the offensive began, the prime minister’s office said in a statement.

“(Netanyahu) expressed his deep appreciation for the U.S. position that Israel has a right to defend itself and thanked him for American aid in purchasing Iron Dome batteries,” the statement added.

The two leaders have had a testy relationship and have been at odds over how to curb Iran’s nuclear program.

A White House official said on Saturday Obama called Turkish Prime Minister Tayyip Erdogan to discuss how the two countries could help bring an end to the Gaza conflict.

Ben Rhodes, White House deputy national security adviser, told reporters that Washington “wants the same thing as the Israelis want”, an end to rocket attacks from Gaza. He said the United States is emphasizing diplomacy and “de-escalation”.

In Berlin, a spokesman for German Chancellor Angela Merkel said she had spoken to Netanyahu and Egypt’s Mursi, stressing to the Israeli leader that Israel had a right to self-defense and that a ceasefire must be agreed as soon as possible to avoid more bloodshed.

U.N. Secretary-General Ban Ki-moon is expected to visit Israel and Egypt next week to push for an end to the fighting in Gaza, U.N. diplomats said on Friday.

The Israeli military said 492 rockets fired from Gaza have hit Israel since the operation began. Iron Dome intercepted another 245.

In Jerusalem, targeted by a Palestinian rocket on Friday for the first time in 42 years, there was little outward sign on the Jewish Sabbath that the attack had any impact on the usually placid pace of life in the holy city.

Some families in Gaza have abandoned their homes – some of them damaged and others situated near potential Israeli targets – and packed into the houses of friends and relatives.

(Additional reporting by Dan Williams and Douglas Hamilton in Tel Aviv, Allyn Fisher-Ilan in Jerusalem, Jeff Mason aboard Air Force One, Writing by Jeffrey Heller; editing by Crispian Balmer)

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Lady Gaga tweets some racy images before concert

BUENOS AIRES, Argentina (AP) — Lady Gaga’s tweets were getting a lot of attention ahead of her Buenos Aires concert Friday night.

The Grammy-winning entertainer has more than 30 million followers on Twitter and that’s where she shared a link this week to a short video showing her doing a striptease and fooling around in a bathtub with two other women.

She told her followers that it’s a “surprise for you, almost ready for you to TASTE.”

Then, in between concerts in Brazil and Argentina, she posted a picture Thursday on her Twitter page showing her wallowing in her underwear and impossibly high heels on top of the remains of what appears to be a strawberry shortcake.

“The real CAKE isn’t HAVING what you want, it’s DOING what you want,” she tweeted.

Lady Gaga wore decidedly unglamorous baggy jeans and a blouse outside her Buenos Aires hotel Thursday as three burly bodyguards kept her fans at bay. Another pre-concert media event where she was supposed to be given “guest of honor” status by the city government Friday afternoon was cancelled.

After Argentina, she is scheduled to perform in Santiago, Chile; Lima, Peru; and Asuncion, Paraguay, before taking her “Born This Way Ball” tour to Africa, Europe and North America.

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Gaza hospitals stretched, need supplies to treat wounded: WHO

GENEVA (Reuters) – Gaza hospitals are overwhelmed with casualties from Israel‘s bombings and face critical shortages of drugs and medical supplies, the World Health Organization (WHO) said on Saturday.

The U.N. health agency appealed for $ 10 million from donors to meet the need for drugs and supplies over the next three months.

Officials in Gaza said 43 Palestinians, nearly half of them civilians including eight children, had been killed since Israel began its air strikes. Three Israeli civilians were killed by a rocket fired from the enclave on Thursday.

Israel unleashed its massive air campaign on Wednesday with the declared goal of deterring Hamas, the Palestinian Islamist group that runs the Gaza Strip, from launching rockets that have plagued its southern communities for years.

The WHO, quoting Health Ministry officials in Gaza, said 382 people have been injured – 245 adults and 137 children.

“Many of those injured have been admitted to hospitals with severe burns, injuries from collapsing buildings and head injuries,” the WHO said in a statement issued in Geneva.

Health authorities have declared an emergency situation in all hospitals to cope with patients, it said.

“Before the hostilities began, health facilities were severely over stretched mainly as a result of the siege of Gaza,” the WHO said. Israel maintains a tight blockade on the Gaza Strip with the help of neighboring Egypt.

The Gaza Ministry of Health‘s supplies of many life-saving drugs and disposable equipment were at “zero stock”, it said.

“The Ministry of Health has postponed all elective surgeries due to the emergency and shortages in anaesthesia drugs,” it said. Non-urgent cases are being transferred to hospitals run by aid groups and health personnel have been asked to report to the nearest health facility for extended shifts, it said.

“WHO appeals to the international and regional community for urgent financial support to provide essential medicines to cover pre-existing shortages, as well as emergency supplies for treating casualties and the chronically ill,” it said.

(Reporting by Stephanie Nebehay; Editing by Alison Williams)

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Israel bombards Gaza Strip, shoots down rocket

GAZA CITY, Gaza Strip (AP) — Israel destroyed the headquarters of Hamas' prime minister and blasted a sprawling network of smuggling tunnels in the southern Gaza Strip on Saturday, broadening a blistering four-day-old offensive against the Islamic militant group even as diplomatic efforts to broker a cease-fire appeared to be gaining steam.

In neighboring Egypt, President Mohammed Morsi hosted leaders from Hamas and two key allies, Qatar and Turkey, to seek a way to end the fighting.

"There are discussions about the ways to bring a cease-fire soon, but there are no guarantees until now," Morsi said at a news conference. He said he was working with Turkey, Arab countries, the U.S., Russia and western European countries to halt the fighting.

Israel launched the operation on Wednesday in what it said was an effort to end months of rocket fire out of the Hamas-ruled territory. It began the offensive with an unexpected airstrike that killed Hamas' powerful military chief, and since then has relentlessly targeted suspected rocket launchers and storage sites.

In all, 46 Palestinians, including 15 civilians, have been killed and more than 400 civilians wounded, according to medical officials. Three Israeli civilians have been killed and more than 50 wounded.

Israeli military officials expressed satisfaction with their progress Saturday, claiming they have inflicted heavy damage to Hamas.

"Most of their capabilities have been destroyed," Maj. Gen. Tal Russo, Israel's southern commander, told reporters. Asked whether Israel is ready to send ground troops into Gaza, he said: "Absolutely."

The White House said President Barack Obama was also in touch with the Egyptian and Turkish leaders. The U.S. has solidly backed Israel so far.

Speaking on Air Force One, deputy national security adviser Ben Rhodes said that the White House believes Israel "has the right to defend itself" against attack and that the Israelis will make their own decisions about their "military tactics and operations."

The White House, which like Israel considers Hamas a terrorist organization, also continued to support Israel. "We believe Israel has a right to defend itself, and they'll make their own decisions about the tactics they use in that regard," deputy national security adviser Ben Rhodes told reporters on Air Force One.

Despite the bruising offensive, Israel has failed to slow the barrages of rockets from Gaza.

The Israeli military said 160 rockets were launched into Israel on Saturday, raising the total number to roughly 500 since this week's fighting began. Eight Israelis, including five civilians, were lightly wounded Saturday, the army said.

Israel carried out at least 300 airstrikes on Saturday, the military said, and it broadened its array of targets. One air raid flattened the three-story office building used by Hamas' prime minister, Ismail Haniyeh. He was not inside the building at the time.

In southern Gaza, aircraft went after the tunnels that militants use to smuggle in weapons and other contraband from neighboring Egypt. Tunnel operators said the intensity of the bombing was unprecedented, and that massive explosions could be heard kilometers (miles) away, both in Gaza and in Egypt.

The operators, speaking on condition of anonymity because of the illicit nature of their business, said they cannot approach the tunnel area to assess the damage, but the blasts appeared to be more powerful than in Israel's last major push to destroy the tunnels during a previous offensive four years ago. The tunnels are a key lifeline for Hamas, bringing in both weapons and supporting a lucrative trade that helps fund the group's activities.

Missiles also smashed into two small security facilities and the massive Hamas police headquarters in Gaza City, setting off a huge blaze that engulfed nearby houses and civilian cars parked outside, the Interior Ministry reported. No one was inside the buildings.

Air attacks knocked out five electricity transformers, cutting off power to more than 400,000 people in southern Gaza, according to the Gaza electricity distribution company. People switched on backup generators for limited electrical supplies.

Hamas has unveiled an arsenal of more powerful, longer-range rockets this week, and for the first time has struck at Israel's two largest cities, Jerusalem and Tel Aviv. Both cities, more than 70 kilometers (45 miles) from Gaza, had previously been beyond rocket range.

In a psychological boost for Israel, a new rocket-defense system known as "Iron Dome" knocked down a rocket headed toward Tel Aviv, eliciting cheers from relieved residents huddled in fear after air raid sirens sounded in the city.

Associated Press video showed a plume of smoke following an intercepting missile out of a rocket-defense battery deployed near the city, followed by a burst of light overhead as it struck its target.

Police said a second rocket also targeted Tel Aviv. It was not clear where it landed or whether it was shot down. No injuries were reported. It was the third straight day the city was targeted.

Israel says the Iron Dome system has shot down some 250 of 500 rockets fired toward the country this week, most in southern Israel near Gaza.

Saturday's interception was the first time Iron Dome has been deployed in Tel Aviv. The battery was a new upgraded version that was only activated on Saturday, two months ahead of schedule, the Defense Ministry said.

Israel has vowed to stage a ground invasion, a scenario that would bring the scale of fighting closer to that of a war four years ago. Hamas was badly bruised during that conflict but has since restocked its arsenal with more and better weapons. Five years after seizing control of Gaza, it has also come under pressure from smaller, more militant groups to prove its commitment to fighting Israel as it turns its focus to governing the seaside strip.

Israel's Defense Minister Ehud Barak has authorized the emergency call-up of up to 75,000 reserve troops ahead of a possible ground offensive. Israel has massed thousands of troops and dozens of tanks and armored vehicles along the border in recent days.

Egypt, which is led by Hamas' parent movement, the Muslim Brotherhood, has been spearheading efforts to forge a cease-fire. Morsi has vowed to stand strong with the people of Gaza and this week recalled Cairo's ambassador from Israel to protest the offensive.

Quietly, though, non-Muslim Brotherhood members in Morsi's government are said to be pushing Hamas to end its rocket fire on Israel. Morsi is under pressure not to go too far and risk straining ties with Israel's ally, the United States.

The Hamas website said Saturday that its leader, Khaled Meshaal, met with the head of Egyptian intelligence for two hours Saturday in Cairo, a day after the Egyptian official was in the Gaza Strip trying to work out an end to the escalation in violence.

Hamas has not immediately accepted Egypt's proposal for a cease-fire, but the group's website said it could end its rocket fire if Israel agrees to end "all acts of aggression and assassination" and lift its five-year Israeli blockade on Gaza. Egypt will present the Hamas position to Israeli officials.

Israeli officials say they are not interested in a "timeout," and want firm guarantees that the rocket fire, which has paralyzed life in an area home to 1 million Israelis, finally ends. Past cease-fires have been short lived.

Israeli Prime Minister Benjamin Netanyahu said he spoke with the leaders of Britain, Poland, Portugal, Bulgaria to press his case. "No government in the world would allow a situation where its population lives under the constant threat of rockets," Netanyahu told them, according to a statement from his office.

The diplomatic activity in Cairo illustrated Hamas' rising influence in a changing Middle East. The Arab Spring has brought Islamists to power and influence across the region, helping Hamas emerge from years of isolation.

Morsi warned that a ground operation by Irael will have "repercussions" across the region. "All must realize the situation is different than before, and the people of the region now are different than before and the leaders are different than before," he said at a joint press conference with Turkey's Islamist prime minister, Recep Tayyip Erdogan. Erdogan, like Morsi, leads an Islamist government that has chilly diplomatic ties with Israel.

On Friday, Morsi sent his prime minister to Gaza on a solidarity mission with Hamas. And on Saturday, Tunisia's Foreign Minister Rafik Abdessalem visited Gaza as well.

___

Federman reported from Jerusalem. Associated Press writers Karin Laub in Gaza City and Aya Batrawy in Cairo contributed reporting.

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Israel moves on reservists after rockets target cities

GAZA/JERUSALEM (Reuters) – Israeli ministers were on Friday asked to endorse the call-up of up to 75,000 reservists after Palestinian militants nearly hit Jerusalem with a rocket for the first time in decades and fired at Tel Aviv for a second day.

The rocket attacks were a challenge to Israel‘s Gaza offensive and came just hours after Egypt‘s prime minister, denouncing what he described as Israeli aggression, visited the enclave and said Cairo was prepared to mediate.

Israel’s armed forces announced that a highway leading to the Gaza Strip and two roads bordering the enclave would be off-limits to civilian traffic until further notice.

Tanks and self-propelled guns were seen near the border area on Friday, and the military said it had already called 16,000 reservists to active duty.

Prime Minister Benjamin Netanyahu convened senior cabinet ministers in Tel Aviv after the rockets struck to decide on widening the Gaza campaign.

Political sources said ministers were asked to approve the mobilization of up to 75,000 reservists, in what could be preparation for a possible ground operation.

No decision was immediately announced and some commentators speculated in the Israeli media the move could be psychological warfare against Gaza’s Hamas rulers. A quota of 30,000 reservists had been set earlier.

Israel began bombing Gaza on Wednesday with an attack that killed the Hamas military chief. It says its campaign is in response to Hamas missiles fired on its territory. Hamas stepped up rocket attacks in response.

Israeli police said a rocket fired from Gaza landed in the Jerusalem area, outside the city, on Friday.

It was the first Palestinian rocket since 1970 to reach the vicinity of the holy city, which Israel claims as its capital, and was likely to spur an escalation in its three-day old air war against militants in Gaza.

Rockets nearly hit Tel Aviv on Thursday for the first time since Saddam Hussein’s Iraq fired them during the 1991 Gulf War. An air raid siren rang out on Friday when the commercial centre was targeted again. Motorists crouched next to cars, many with their hands protecting their heads, while pedestrians scurried for cover in building stairwells.

The Jerusalem and Tel Aviv strikes have so far caused no casualties or damage, but could be political poison for Netanyahu, a conservative favored to win re-election in January on the strength of his ability to guarantee security.

“The Israel Defence Forces will continue to hit Hamas hard and are prepared to broaden the action inside Gaza,” Netanyahu said before the rocket attacks on the two cities.

Asked about Israel massing forces for a possible Gaza invasion, Hamas spokesman Sami Abu Zuhri said: “The Israelis should be aware of the grave results of such a raid and they should bring their body bags.”

Officials in Gaza said 28 Palestinians had been killed in the enclave since Israel began the air offensive with the declared aim of stemming surges of rocket strikes that have disrupted life in southern Israeli towns.

The Palestinian dead include 12 militants and 16 civilians, among them eight children and a pregnant woman. Three Israelis were killed by a rocket on Thursday. A Hamas source said the Israeli air force launched an attack on the house of Hamas’s commander for southern Gaza which resulted in the death of two civilians, one a child.

SOLIDARITY VISIT

A solidarity visit to Gaza by Egyptian Prime Minister Hisham Kandil, whose Islamist government is allied with Hamas but also party to a 1979 peace treaty with Israel, had appeared to open a tiny window to emergency peace diplomacy.

Kandil said: “Egypt will spare no effort … to stop the aggression and to achieve a truce.”

But a three-hour truce that Israel declared for the duration of Kandil’s visit never took hold. Israel said 66 rockets launched from the Gaza Strip hit its territory on Friday and a further 99 were intercepted by the Iron Dome anti-missile system.

Israel denied Palestinian assertions that its aircraft struck while Kandil was in the enclave.

Israel Radio’s military affairs correspondent said the army’s Homefront Command had told municipal officials to make civil defence preparations for the possibility that fighting could drag on for seven weeks. An Israeli military spokeswoman declined to comment on the report.

The Gaza conflagration has stoked the flames of a Middle East already ablaze with two years of Arab revolution and a civil war in Syria that threatens to leap across borders.

It is the biggest test yet for Egypt’s new President Mohamed Mursi, a veteran Islamist politician from the Muslim Brotherhood who was elected this year after last year’s protests ousted military autocrat Hosni Mubarak.

Egypt’s Muslim Brotherhood are spiritual mentors of Hamas, yet Mursi has also pledged to respect Cairo’s 1979 peace treaty with Israel, seen in the West as the cornerstone of regional security. Egypt and Israel both receive billions of dollars in U.S. military aid to underwrite their treaty.

Mursi has vocally denounced the Israeli military action while promoting Egypt as a mediator, a mission that his prime minister’s visit was intended to further.

A Palestinian official close to Egypt’s mediators told Reuters Kandil’s visit “was the beginning of a process to explore the possibility of reaching a truce. It is early to speak of any details or of how things will evolve”.

Hamas fighters are no match for the Israeli military. The last Gaza war, involving a three-week long Israeli air blitz and ground invasion over the New Year period of 2008-2009, killed more than 1,400 Palestinians, mostly civilians. Thirteen Israelis died.

Tunisia’s foreign minister was due to visit Gaza on Saturday “to provide all political support for Gaza” the spokesman for the Tunisian president, Moncef Marzouki, said in a statement.

The United States asked countries that have contact with Hamas to urge the Islamist movement to stop its rocket attacks.

Hamas refuses to recognize Israel’s right to exist. By contrast, Palestinian President Mahmoud Abbas, who rules in the nearby West Bank, does recognize Israel, but peace talks between the two sides have been frozen since 2010.

Abbas’s supporters say they will push ahead with a plan to have Palestine declared an “observer state” rather than a mere “entity” at the United Nations later this month.

(Additional reporting by Maayan Lubell, Jeffrey Heller and Crispian Balmer in Jerusalem; Writing by Jeffrey Heller; Editing by Giles Elgood)

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Robert Pattinson looks for danger after “Twilight”

LOS ANGELES (Reuters) – Robert Pattinson has set young hearts aflutter as the teen vampire Edward Cullen in the “Twilight Saga” films, but as the sun sets on the franchise that launched his career, the actor is looking for more grown-up and “dangerous” roles.

“Breaking Dawn – Part 2,” released this week, is the fifth and final in the series, and Edward’s character shifts from brooding, tormented lover to a contented husband and father who must protect his family from an ancient vampire clan.

But Pattinson, 26, still has those rakish good looks that drew a screaming fan base and made him a tabloid fixture. While the avid fan excitement around the “Twilight” series overwhelms him, the British actor hopes his audience will follow him as he moves on.

“It’s all about control. Now, I don’t feel like I have any control whatsoever,” he told Reuters with a laugh.

“They’re a very ardent fan base, so to figure out a way to harness that vehement audience, it’s definitely an important thing.”

Pattinson became a pinup as the angst-ridden Edward, but said he wasn’t worried he might be typecast as the perpetual brooding hero. “I’m not particularly brooding in my real life,” he said.

The actor has already been laying the ground for a career beyond “Twilight.” He played a 19th century French gigolo in “Bel Ami” and a billionaire with an existential crisis in David Cronenberg‘s “Cosmopolis,” although both films fared poorly at the box office earlier this year.

Next up is a drama, “Map to the Stars,” again with Cronenberg, and “The Rover,” a Western-style action movie set in the Australian desert.

“Everything I’ve signed up for now is very physical, because I feel like I’ve done quite a few things where I’m quite still. I’m trying to find people that are doing things that feel dangerous,” Pattinson said.

ROMANCE ON AND OFF SCREEN

Away from the series with its apple motif, symbolizing forbidden love, Pattinson’s fame has also been fueled by his off-screen romance with “Twilight” co-star Kristen Stewart, 22, who plays Bella Swan.

Their relationship was thrust into the spotlight in the summer when Stewart publicly admitted she had an affair with her married “Snow White and the Huntsman” director, Rupert Sanders.

The actress apologized in a rare, heartfelt public statement but the affair shocked “Twilight” fans. Pattinson and Stewart have since reconciled, and the paparazzi have spotted them together, but they have stayed mum on their relationship.

“I just try and avoid it,” Pattinson said when asked about the scrutiny of his personal life.

“I don’t think it’s good in terms of a career as an actor. I think being in gossip magazines – I don’t like the whole industry, I think it’s a lazy industry, and it’s a weird media consumer culture,” the actor said.

“(Success) is so much based on luck as an actor. No one knew that the audience would connect to the ‘Twilight’ series the way that they did … it’s just luck, you’ve got to do the things that interest you.”

For now, Pattinson is coming to terms with saying goodbye to the franchise.

“It sounds cheesy, but it’s been such a life-changing experience where you share a bond with people, it’s weird. I remember hearing about ‘Lord of the Rings,’ they all got tattoos … that’d be so funny, maybe we could get a little apple, a ‘tramp stamp’ with an apple,” the actor mused, laughing.

(Reporting by Piya Sinha-Roy, Editing by Jill Serjeant, Gary Hill)

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EU drug regulator OKs Novartis’ meningitis B shot

LONDON (AP) — Europe‘s top drug regulator has recommended approval for the first vaccine against meningitis B, made by Novartis AG.

There are five types of bacterial meningitis. While vaccines exist to protect against the other four, none has previously been licensed for type B meningitis. In Europe, type B is the most common, causing 3,000 to 5,000 cases every year.

Meningitis mainly affects infants and children. It kills about 8 percent of patients and leaves others with lifelong consequences such as brain damage.

In a statement on Friday, Andrin Oswald of Novartis said he is “proud of the major advance” the company has made in developing its vaccine Bexsero. It is aimed at children over two months of age, and Novartis is hoping countries will include the shot among the routine ones for childhood diseases such as measles.

Novartis said the immunization has had side effects such as fever and redness at the injection site.

Recommendations from the European Medicines Agency are usually adopted by the European Commission. Novartis also is seeking to test the vaccine in the U.S.

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Israelis, Palestinians lob threats via Twitter

RT @ElizabethCNN: Tamils want inquiry after UN says it 'failed civilians' in bloody Sri Lanka civil war - http://t.co/Pd6AAWBT http://t ...

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France urges Mali to step up talks with rebels

PARIS (AP) — France‘s president called Thursday for stepped-up talks between Mali’s government and any leaders from its breakaway north “who reject terrorism,” even as African nations geared up for a possible military operation against Islamic extremists there.

President Francois Hollande‘s comments suggested a growing openness to dialogue with the extremists, but he remained committed to supporting the military planning effort.

Northern Mali fell to Islamic extremists in April, after coup leaders toppled the government in Bamako, Mali‘s capital. Fearing that northern Mali could become the latest hotbed of terrorism, France has been a driving force in international efforts to bolster Mali’s army to drive the Islamists from power.

Hollande spoke with interim Mali President Dioncounda Traore by phone on Thursday, partly to detail European efforts to help strengthen Mali’s army.

In recent days, representatives from the most moderate of three al-Qaida-linked groups that control northern Mali have been meeting with Burkina Faso‘s president, appointed as a mediator.

“France reiterates its wish that political dialogue will intensify between Malian authorities and representatives of northern populations who reject terrorism,” Hollande’s office said in a statement. “The acceleration of this dialogue must accompany the progress in African military-planning efforts.”

Earlier this week, the African Union approved a plan that calls for 3,300 African troops to be deployed in order to win back Mali’s north. European countries including France and Germany have expressed a willingness to provide military trainers and logistics support, but have stopped short of committing combat troops.

France, like many European countries, fears that the arid, northern Sahel region of Mali could become a breeding ground for terrorism, where al-Qaida and its allies could plot hostage-takings and attacks in Europe or beyond.

France has millions of people whose families hail from former French colonies in north and west Africa. Authorities have long been concerned that French-born militants could travel abroad for terrorism training and return home later to possibly carry out attacks.

French authorities are already investigating two French citizens who were arrested in Mali and neighboring Niger and are suspected of seeking to join up with the al-Qaida-linked extremists, a judicial official told The Associated Press.

Ibrahim Ouattara, a 24-year-old native of the northern Paris suburb of Aubervilliers who has dual French and Malian nationality, was arrested inside Mali this month and remains in custody there, the official said.

Separately, a 27-year-old Frenchman was arrested in August in Niger and has since been handed over to authorities in France, the official said, speaking on condition of anonymity because she was not authorized to discuss terrorism cases publicly.

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Drug charges dropped against Jon Bon Jovi’s daughter

(Reuters) – Drug charges against the daughter of rock star Jon Bon Jovi were dropped on Thursday, a day after she suffered a suspected heroin overdose, officials in New York said.

Oneida County District Attorney Scott D. McNamara said in a statement that Stephanie Bongiovi could not be charged because New York law prohibits the prosecution of people who had overdosed and were in possession of small amounts of drugs.

Bongiovi, 19, was found unresponsive in a dormitory room at Hamilton College in Clinton, New York, early on Wednesday and was later booked on misdemeanor charges of possession of a controlled substance (heroin), marijuana possession and criminal use of drug paraphernalia, which were found in the room.

A message left with the singer’s representative was not immediately returned.

Heroin and marijuana charges against fellow student Ian S. Grant, 21, in connection with Bongiovi’s case were also dropped as a witness or victim to a drug or alcohol overdose cannot be prosecuted in New York.

Bongiovi is the oldest of four children of Bon Jovi and wife Dorothea Hurley.

(Reporting By Eric Kelsey, editing by Jill Serjeant and Andre Grenon)

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People overestimate benefits of prevention

NEW YORK (Reuters Health) – Patients asked to estimate how many lives would be saved through cancer screening or how many hip fractures can be prevented with bone-building medication mostly overestimate the benefits of these preventive measures, according to a survey of New Zealanders.

Annette O’Connor of the University of Ottawa, who studies how patients weigh risk and make decisions, said she would expect that people would overvalue any given prevention effort.

“Most people would overestimate because they’re told about their benefits, but with no numbers…so why would you think that it’s going to be really low?” said O’Connor, who was not involved in the new study.

Doctors, nurses and others who communicate health information often don’t detail how much a given test or drug can help, but only say that people ought to have it, O’Connor told Reuters Health.

“I think it’s led to more people taking part in screening or availing themselves of preventive medication than would have been the case if they were presented the information in more meaningful terms,” said Dr. Ben Hudson, the new study’s lead author and a professor at the University of Otago in Christchurch, New Zealand.

“I would also be concerned that it’s led to people having over-heightened expectations of what these things can achieve, and that may lead to disappointment when the inevitable breast cancer happens despite screening,” he added.

Hudson said that in talking with his patients about screening, he found they were surprised by how small the benefits were.

To get a broader sense of patients’ expectations for preventive measures, Hudson and his colleagues asked 354 people about the benefits of breast cancer screening with mammography, bowel cancer screening with stool testing, taking antihypertension medication and taking bone-strengthening medication.

Specifically, participants were asked to imagine scenarios in which 5,000 people between ages 50 and 70 undergo one of these preventive interventions for 10 years, then asked how many “events” the participants thought would be avoided as a result of the measure.

For three of the four interventions in the survey, the event to be avoided was death and in the case of bone drugs, it was hip fracture.

For breast cancer screening, only seven percent of the participants answered in the correct range of one to five lives being saved with screening, whereas 90 percent overestimated how many lives would be saved. Fully a third thought that 1,000 deaths would be averted.

The numbers were similar for bowel cancer screening, which is thought to save five to 10 lives for every 5,000 people tested, Hudson’s group reports in the Annals of Family Medicine.

Eighty-two percent of participants overestimated the number of fractures prevented by bone-strengthening medication, which in reality is about 50 for every 5,000 patients given the drug.

And 69 percent of participants reported that 500 or more lives would be saved if 5,000 people took blood pressure medication, when the correct range should have been 50 to 100.

“It’s probably unreasonable to expect people to make an accurate guess at the absolute number (of lives saved or fractures prevented), but what we found was a consistent trend toward higher levels,” Hudson told Reuters Health.

“I don’t think most patients are likely to have access to good numerical data presented in a simple and informative way. I think that’s part of the problem here,” he said.

The U.S. Preventive Services Task Force (USPSTF) issues screening recommendations and other guidelines for disease prevention, which doctors, nurses and public health groups often consult when counseling patients.

A survey of U.S. physicians found that most of them don’t fully grasp what the numbers mean when it comes to cancer screening (see Reuters Health story of March 5, 2012).

O’Connor said that when health care professionals repeat these guidelines to patients, they often don’t include the numbers when talking about benefits or they only refer to something called the “relative risk.”

The relative risk describes the change in a person’s chances of developing a disease, but it does not give any sense of how much risk that person had to begin with.

For example, a “50 percent reduction in risk” may be less significant than it sounds if a person’s absolute risk for a condition – how likely they are to develop it at some point in life – was originally five percent, and drops to 2.5 percent.

“Professionals and people who provide health information need to know absolute benefits,” O’Connor said.

The relative risk of dying from breast cancer is 17 percent lower among a population of women aged 50 to 69 who get screened, compared to women who do not get screened, for instance.

But in absolute terms, that means that instead of 23 in 100,000 women dying of breast cancer, screening would reduce that number to 19 in 100,000 women.

Hudson said that one of the potential problems that can arise when people overvalue a test is that if recommendations are scaled back because of insufficient benefits, people get upset.

In 2009, for instance, the USPSTF changed its guidelines for regular mammograms from beginning at age 40 to beginning at 50, because the number of lives saved through screening during that extra decade of life was too small compared to the potential harms from the screening itself and follow-up procedures.

A survey of women at the time found that most of them considered the new guidelines to be “unsafe,” at least in part because they feared that insurers would no longer cover screening for women in their 40s who wanted it.

“The other thing that happens when you have an established screening program for which people have heightened expectations, it becomes very politically difficult to make any changes insofar as recommending reduced access, even when the evidence is pretty convincing that the outcomes are better,” said Hudson.

Hudson advocated for better informing patients of the benefits and harms of any preventive intervention.

“I have a feeling this would all be easier if we could present (patients) with this information, trust them with their decisions and support them in doing so,” he said.

SOURCE: http://bit.ly/XINd5u Annals of Family Medicine, November/December 2012.

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U.S. backs Israeli response to Gaza attacks

Israeli soldiers ride on top of an armored personnel carrier close to the Israel-Gaza border, in southern Israel. …The White House on Thursday threw its full support behind Israel's military response to a barrage of rockets fired by the Islamist Palestinian movement Hamas that rules the Gaza Strip. Deputy National Security Adviser for Strategic Communications Ben Rhodes said it would be "up to the Israeli government" whether to follow up punishing airstrikes with a ground assault.

"Our view is that the Israelis have the right of self-defense when their citizens are faced with the threat of indiscriminate rocket fire from within Gaza," Rhodes told reporters on a conference call.

Asked whether the Obama administration would have any issues with an Israeli ground assault, Rhodes replied that "ultimately, it's up to the Israeli government to make determinations about how they're going to carry out their military objectives."

The Associated Press has reported that Hamas fired more than 200 rockets on Thursday, killing three people, and that Israel seemed to be gearing up for a ground invasion of Gaza. The escalating conflict amounted to President Barack Obama's first major foreign policy test since winning re-election Nov. 6. Rhodes said American officials were in close consultation with their Israeli counterparts "to have an understanding of their plans going forward." The Obama administration has been in discussions with Turkey, Egypt and "some of our European partners," he said, thought to have sway over Hamas in order to get them to urge the militant organization to halt its rocket attacks.

"At the United Nations, where this is being discussed, we've sought to keep the focus where it should be—which is on Hamas's rocket fire as the precipitating cause here," Rhodes explained.

"What we've also said is that the best course of action would be for there to be a general de-escalation of the violence, but that the onus is on Hamas—and those with influence over Hamas—to help bring about that de-escalation, so that we don't see a widening conflict," he told reporters. "So we certainly want to see a de-escalation, we certainly want to see a broader conflict avoided."

The official noted that the White House has urged Israel to take "all steps ... to avoid civilian casualties." He added, "And we deeply regret the loss of life on the Israeli and Palestinian side."

Israeli Ambassador to the United States Michael Oren briefed key senators on the operation. The lawmakers—Democrats and Republicans—released a joint statement expressing "solidarity" with Israel while warning that "escalation will only lead to further suffering on both sides."

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Egypt recalls envoy to Israel after Gaza strike

CAIRO (AP) — Egypt has recalled its ambassador to Israel after an Israeli airstrike killed the military commander of Gaza‘s ruling Hamas.

In a statement read on state TV late Wednesday, spokesman Yasser Ali said that President Mohammed Morsi recalled the ambassador and asked the Arab League‘s Secretary General to convene an emergency ministerial meeting in the wake of the Gaza violence.

Morsi also called for an immediate cease fire between Israel and Hamas, an offshoot of Morsi’s Muslim Brotherhood. Israel says it struck in response to rocket attacks from Gaza.

Hours earlier, Morsi’s Muslim Brotherhood group denounced the Israeli airstrike as a “crime that requires a quick Arab and international response to stem these massacres.”

Relations between Israel and Egypt have deteriorated since longtime President Hosni Mubarak was ousted last year.

Middle East News Headlines – Yahoo! News

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Steve Wozniak, Danny Trejo to appear in 8-bit video game

LOS ANGELES (TheWrap.com) – When it comes to the iPhone, Steve Jobs created it, but Steve Wozniak got game.

The Apple co-founder will appear as a playable character in an upcoming iOS video game “Danny Trejo‘s Vengeance: Woz with a Coz.”

The game, slated to be released around November 22, puts Wozniak alongside “Machete” star Trejo in an 8-bit mobile game, fighting a city full of enemies with an assortment of weapons.

The plot is simple: “Woz” is forced to save his wife, J-Woz, after she is kidnapped by street thugs. Teaming up with Vengence, Woz tears up Fusion City in his quest to rescue her.

“Featuring an over-the-top, old school inspired action combined with a retro 8-bit and exciting gritty art style, players will enjoy Woz’s brain power, translator apps, Danny Trejo’s machetes, guns and other crazy upgrades,” a Facebook fan page devoted to the game says.

Other playable characters will include musician Baby Bash and MMA World Champion “Suga” Rashad Evans.

Gaming News Headlines – Yahoo! News

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NBC names new top producer for ‘Today’

NEW YORK (AP) — NBC News is staying in-house in its effort to turn around the “Today” show.

The network on Wednesday appointed a 23-year veteran of the morning news show as its new executive producer. Don Nash began working for “Today” as a production assistant in NBC’s Burbank office in 1989 and will now run the four-hour broadcast.

Nash was most recently senior broadcast producer in the show’s control room. He replaces Jim Bell, who shifted to NBC Sports to run its Olympics broadcasts.

After nearly two decades of dominance, “Today” has slipped behind ABC’s “Good Morning America” in the ratings.

NBC also added another layer of management for the show, appointing Alexandra Wallace as the network’s executive in charge of the program.

Entertainment News Headlines – Yahoo! News

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New gene triples risk for Alzheimer’s disease

Scientists have identified a new gene variant that seems to strongly raise the risk for Alzheimer’s disease, giving a fresh target for research into treatments for the mind-robbing disorder.

The problem gene is not common — less than 1 percent of people are thought to have it — but it roughly triples the chances of developing Alzheimer’s compared to people with the normal version of the gene. It also seems to harm memory and thinking in older people without dementia.

The main reason scientists are excited by the discovery is what this gene does, and how that might reveal what causes Alzheimer’s and ways to prevent it. The gene helps the immune system control inflammation in the brain and clear junk such as the sticky deposits that are the hallmark of the disease. Mutations in the gene may impair these tasks, so treatments to restore the gene’s function and quell inflammation may help.

“It points us to potential therapeutics in a more precise way than we’ve seen in the past,” said Dr. William Thies, chief medical and scientific officer of the Alzheimer’s Association, which had no role in the research. Years down the road, this discovery will likely be seen as very important, he predicted.

It is described in a study by an international group published online Wednesday by the New England Journal of Medicine.

About 35 million people worldwide have dementia, and Alzheimer’s is the most common type. In the U.S., about 5 million have Alzheimer’s. Medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.

Until now, only one gene — ApoE — has been found to have a big impact on Alzheimer’s risk. About 17 percent of the population has at least one copy of the problem version of this gene but nearly half of all people with Alzheimer’s do. Other genes that have been tied to the disease raise risk only a little, or cause the less common type of Alzheimer’s that develops earlier in life, before age 60.

The new gene, TREM2, already has been tied to a couple other forms of dementia. Researchers led by deCODE Genetics Inc. of Iceland honed in on a version of it they identified through mapping the entire genetic code of more than 2,200 Icelanders.

Further tests on 3,550 Alzheimer’s patients and more than 110,000 people without dementia in several countries, including the United States, found that the gene variant was more common in Alzheimer’s patients.

“It’s a very strong effect,” raising the risk of Alzheimer’s by three to four times — about the same amount as the problem version of the ApoE gene does, said Dr. Allan Levey, director of an Alzheimer’s program at Emory University, one of the academic centers participating in the research.

Researchers also tested more than 1,200 people over age 85 who did not have Alzheimer’s disease and found that those with the variant TREM2 gene had lower mental function scores than those without it. This adds evidence the gene variant is important in cognition, even short of causing Alzheimer’s.

“It’s another piece in the puzzle. It suggests the immune system is important in Alzheimer’s disease,” said Andrew Singleton, a geneticist with the National Institute on Aging, which helped pay for the study.

One prominent scientist not involved in the study — Dr. Rudolph Tanzi, a Harvard Medical School geneticist and director of an Alzheimer’s research program at Massachusetts General Hospital — called the work exciting, but added a caveat.

“I would like to see more evidence that this is Alzheimer’s” rather than one of the other dementias already tied to the gene, Tanzi said. Autopsy or brain imaging tests can show whether the cases attributed to the gene variant are truly Alzheimer’s or misdiagnosed, he said.

___

Online:

Medical journal: http://www.nejm.org

Alzheimer’s info: http://www.alzheimers.gov

Alzheimer’s Association: http://www.alz.org

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

Health News Headlines – Yahoo! News

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Clinton-Lewinsky 'spinners' resurface

WASHINGTON (Reuters) - It's a case of déjà vu in D.C.: some of the same high-profile, high-priced handlers who played supporting roles in the scandal over President Bill Clinton's affair with intern Monica Lewinsky have re-emerged in the sex scandal that has toppled one U.S. national security chief and threatens another.

It is unclear what will be the roles of the expensive legal and crisis-management talent drawn into the uproar over the relationships between former CIA director David Petraeus and Marine General John Allen and two female acquaintances. Neither Republicans nor Democrats in Congress appear to have an appetite for another year-long Monica-style media spectacle.

The latest scandal began with an FBI investigation into cyber-harassment, and indications so far are that ultimately the inquiry will produce no criminal charges.

Nonetheless, both women at the center of attention - Petraeus biographer and former mistress Paula Broadwell and Tampa socialite Jill Kelley, the woman to whom Broadwell is alleged to have sent suspected harassing emails - have turned for advice to veteran Washington lawyers and spin doctors with connections to the Lewinsky brouhaha.

On Monday, a source close to the Kelley family said that two Washington-based players in the Lewinsky scandal, trial lawyer Abbe Lowell and public relations adviser Judy Smith, were working for Kelley.

A day later, a Washington law firm which represented Lewinsky herself confirmed that one of its partners, Robert F. Muse, was representing Broadwell. The three advisors either were unavailable for comment or declined to comment.

It is not known whether Petraeus or Allen, who is the top U.S. military commander in Afghanistan, have retained attorneys.

 

A complaint by Kelley to the FBI about the harassing emails sparked an investigation that implicated Petraeus in a career-ending affair with Broadwell.

It also embroiled Kelley herself in the uproar over her still-murky relationship with Allen.

Kelley's lawyer, Lowell, who an insider said she had known for years, served as pro-Clinton Democratic Party chief counsel on a House impeachment inquiry. Recently he won a partial acquittal and partial mistrial for John Edwards, a former Democratic U.S. senator and vice presidential candidate who had been indicted for misusing undeclared campaign funds to support his mistress.

During the Clinton sex scandal, Smith, a one-time press aide to President George H.W. Bush, served as Lewinsky's spokeswoman. Smith also represented NFL quarterback Michael Vick, who was charged and convicted in a dogfighting cruelty case.

Smith also is a model for the main character in the ABC-TV drama "Scandal," a prime-time series in which ace spin-doctor Olivia Pope, along with a team of spies and ex-convicts, not only manages to sort out or cover up sex and spy scandals but also carries on a secret affair with a fictional U.S. president.

Muse's senior partner, Jacob Stein, and another prominent criminal lawyer from a different firm, Plato Cacheris, represented Lewinsky personally in a criminal investigation of Clinton by special prosecutor Kenneth Starr and a congressional inquiry which led to Clinton's impeachment by the House of Representatives but subsequent acquittal by the Senate. Muse himself did not represent Lewinsky, according to Cacheris.

Starr and a substantial special prosecution team pursued Clinton during the Lewinsky scandal. Starr turned his evidence over to the Republican-controlled House, which in a nationally televised broadcast impeached Clinton for high crimes and misdemeanors.

But Republicans could not muster the two-thirds majority in the Senate needed to remove Clinton from office. Republicans later were punished at the polls for what many of them conceded was a perceived overzealousness in pursuing Clinton.

CONGRESS WARY OF SPECTACLE

Lewinsky's lawyers were critical in helping her negotiate a legal thicket that included dealing with Starr's criminal investigators and the impeachment inquiry launched by Congress; she testified in both investigations. Lewinsky was also besieged for months by the media; eventually her team arranged decorous interviews with U.S. and British television networks.

Mindful of how the Lewinsky scandal played out, officials familiar with the views of both senior Democrats and Republicans in Congress say that congressional leaders are keen to avoid turning the scandal into a public extravaganza, even though there remain many unanswered questions.

If there are no public congressional hearings or a criminal prosecution, it is unclear what Broadwell's and Kelley's legal and public relations teams would do, apart from trying to manage news coverage and the hordes of paparazzi and TV cameramen now outside their clients' homes.

Lewinsky's lawyer, Cacheris, told Reuters that from what he could see, at this point Broadwell and Kelley do not know if there will be any charges against them. "These people are getting lawyers to ensure there is no criminal case," he added.

But Eric Dezenhall, a Washington crisis management expert, said some clients did not understand that there was a limit to how much even the most skilled lawyer and public relations specialist could do.

"You have to be very selective in the cases you take because you're going to end up with some very disgruntled clients," Dezenhall said.

(Editing by Warren Strobel and Paul Simao)

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General investigated for emails to Petraeus friend

PERTH, Australia (AP) — In a new twist to the Gen. David Petraeus sex scandal, the Pentagon said Tuesday that the top American commander in Afghanistan, Gen. John Allen, is under investigation for alleged “inappropriate communications” with a woman who is said to have received threatening emails from Paula Broadwell, the woman with whom Petraeus had an extramarital affair.

Defense Secretary Leon Panetta said in a written statement issued to reporters aboard his aircraft, en route from Honolulu to Perth, Australia, that the FBI referred the matter to the Pentagon on Sunday.

Panetta said that he ordered a Pentagon investigation of Allen on Monday.

A senior defense official traveling with Panetta said Allen’s communications were with Jill Kelley, who has been described as an unpaid social liaison at MacDill Air Force Base, Fla., which is headquarters to the U.S. Central Command. She is not a U.S. government employee.

Kelley is said to have received threatening emails from Broadwell, who is Petraeus’ biographer and who had an extramarital affair with Petraeus that reportedly began after he became CIA director in September 2011.

Petraeus resigned as CIA director on Friday.

Allen, a four-star Marine general, succeeded Petraeus as the top American commander in Afghanistan in July 2011.

The senior official, who discussed the matter only on condition of anonymity because it is under investigation, said Panetta believed it was prudent to launch a Pentagon investigation, although the official would not explain the nature of Allen’s problematic communications.

The official said 20,000 to 30,000 pages of emails and other documents from Allen’s communications with Kelley between 2010 and 2012 are under review. He would not say whether they involved sexual matters or whether they are thought to include unauthorized disclosures of classified information. He said he did not know whether Petraeus is mentioned in the emails.

“Gen. Allen disputes that he has engaged in any wrongdoing in this matter,” the official said. He said Allen currently is in Washington.

Panetta said that while the matter is being investigated by the Defense Department Inspector General, Allen will remain in his post as commander of the International Security Assistance Force, based in Kabul. He praised Allen as having been instrumental in making progress in the war.

The FBI’s decision to refer the Allen matter to the Pentagon rather than keep it itself, combined with Panetta’s decision to allow Allen to continue as Afghanistan commander without a suspension, suggested strongly that officials viewed whatever happened as a possible infraction of military rules rather than a violation of federal criminal law.

Allen was Deputy Commander of Central Command, based in Tampa, prior to taking over in Afghanistan. He also is a veteran of the Iraq war.

In the meantime, Panetta said, Allen’s nomination to be the next commander of U.S. European Command and the commander of NATO forces in Europe has been put on hold “until the relevant facts are determined.” He had been expected to take that new post in early 2013, if confirmed by the Senate, as had been widely expected.

Panetta said President Barack Obama was consulted and agreed that Allen’s nomination should be put on hold. Allen was to testify at his confirmation hearing before the Senate Armed Services Committee on Thursday. Panetta said he asked committee leaders to delay that hearing.

NATO officials had no comment about the delay in Allen’s appointment.

“We have seen Secretary Panetta‘s statement,” NATO spokeswoman Carmen Romero said in Brussels. “It is a U.S. investigation.”

Panetta also said he wants the Senate Armed Services Committee to act promptly on Obama’s nomination of Gen. Joseph Dunford to succeed Allen as commander in Afghanistan. That nomination was made several weeks ago. Dunford’s hearing is also scheduled for Thursday.

___

Associated Press writer Slobodan Lekic in Kabul, Afghanistan, contributed to this report.

Asia News Headlines – Yahoo! News

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Twilight cast bids farewell at final premiere

LOS ANGELES (Reuters) – Thousands of screaming fans lined the black carpet late on Monday for the final “Twilight” film premiere as the cast of “Breaking Dawn – Part 2″ bid farewell to the franchise and its loyal followers.

Robert Pattinson, Kristen Stewart, Taylor Lautner and other cast members greeted fans known as “Twi-hards,” many of whom had camped out for days in downtown Los Angeles to catch a glimpse of their favorite actors and see the film before it is released in theaters on Friday.

Breaking Dawn – Part 2 will see the love story of human Bella Swan (Stewart), vampire Edward Cullen (Pattinson) and werewolf Jacob Black (Lautner) come to a tantalizing end, when Bella and Edward are forced to protect their child from an ancient vampire coven.

Stewart, who was finally able to embrace her wild side by playing Bella as a vampire, hoped people would enjoy the ultimate transformation of her character in the film.

“Bella has worked pretty hard to get to the point where they can have it all, and it’s fun to be there. She’s always been human, but now that she’s not, you’re just in full blown vampire land and it feels funny in a great way,” Stewart told Reuters.

More than 2,200 fans from all over the world came to camp out on a concrete plaza in downtown Los Angeles last week, where Twilight movie studio Summit laid out activities and marathon screenings of the previous movies.

All of the film’s main actors spent time signing autographs and posing for photographs with the loyal fans who had camped out in chilly November weather over five days.

Pattinson, who plays vampire Edward Cullen, said he hoped the fans would like the franchise’s swan song.

“I hope they feel it kind of respects them, because I think in a lot of ways that’s what we were thinking when we were making it,” the actor said.

Lautner, who plays werewolf Jacob, said he’d be sad to say goodbye to the films and his character and hoped fans would be happy with the conclusion of the final film.

“I’m feeling fantastic, sad, emotional, there’s a lot of things going on inside of me right now but I’m just trying to soak up every moment because this means the world to me,” Lautner said.

The three lead stars were joined by fellow cast members including Nikki Reed, Ashley Greene, Kellan Lutz, Jackson Rathbone, Michael Sheen and Dakota Fanning, as well as director Bill Condon and author Stephenie Meyer, whose Twilight novels kicked off the franchise and phenomenon.

Meyer said she would miss watching the three lead cast members evolve as actors and characters in the films.

“It’s really been great to watch them grow up, particularly Kristen because her character gets to evolve so much in this film, and to watch her be all powerful and really get to where the character was always meant to go, to be the fiercest of the fierce, was really rewarding for me,” the author said.

(Reporting By Piya Sinha-Roy, editing by Paul Casciato)

Movies News Headlines – Yahoo! News

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Report: FDA wanted to close Mass pharmacy in 2003

WASHINGTON (AP) — Nearly a decade ago, federal health inspectors wanted to shut down the pharmacy linked to a recent deadly meningitis outbreak until it cleaned up its operations, according to congressional investigators.

About 440 people have been sickened by contaminated steroid shots distributed by New England Compounding Center, and more than 32 deaths have been reported since the outbreak began in September, according to the Centers for Disease Control and Prevention. That has put the Framingham, Mass.-based pharmacy at the center of congressional scrutiny and calls for greater regulation of compounding pharmacies, which make individualized medications for patients and have long operated in a legal gray area between state and federal laws.

The House Energy and Commerce Committee released a detailed history of NECC‘s regulatory troubles on Monday, ahead of a meeting Wednesday meeting to examine how the outbreak could have been prevented. The 25-page report summarizes and quotes from FDA and state inspection memos, though the committee declined to release the original documents.

The report shows that after several problematic incidents, Food and Drug Administration officials in 2003 suggested that the compounding pharmacy be “prohibited from manufacturing” until it improved its operations. But FDA regulators deferred to their counterparts in Massachusetts, who ultimately reached an agreement with the pharmacy to settle concerns about the quality of its prescription injections.

The congressional report also shows that in 2003 the FDA considered the company a pharmacy. That’s significant because in recent weeks public health officials have charged that NECC was operating more as a manufacturer than a pharmacy, shipping thousands of doses of drugs to all 50 states instead of small batches of drugs to individual patients. Manufacturers are regulated by the FDA and are subject to stricter quality standards than pharmacies.

The report offers the most detailed account yet of the numerous regulatory complaints against the pharmacy, which nearly date back to its founding in 1998. Less than a year later, the company was cited by the state pharmacy board for providing doctors with blank prescription pads with NECC’s information. Such promotional items are illegal in Massachusetts and the pharmacy’s owner and director, Barry Cadden, received an informal reprimand, according to documents summarized by the committee.

Cadden was subject to several other complaints involving unprofessional conduct in coming years, but first came to the FDA’s attention in 2002. Here are some key events from the report highlighting the company’s early troubles with state and federal authorities:

__ In March of 2002 the FDA began investigating reports that five patients had become dizzy and short of breath after receiving NECC’s compounded betamethasone repository injection, a steroid used to treat joint pain and arthritis that’s different from the one linked to the current meningitis outbreak.

FDA inspectors visited NECC on April 9 and said Cadden was initially cooperative in turning over records about production of the drug. But during a second day of inspections, Cadden told officials “that he was no longer willing to provide us with any additional records,” according to an FDA report cited by congressional investigators. The inspectors ultimately issued a report citing NECC for poor sterility and record-keeping practices but said that “this FDA investigation could not proceed to any definitive resolution,” because of “problems/barriers that were encountered throughout the inspection.”

__ In October of 2002, the FDA received new reports that two patients at a Rochester, N.Y., hospital came down with symptoms of bacterial meningitis after receiving a different NECC injection. The steroid, methylprednisolone acetate, is the same injectable linked to the current outbreak and is typically is used to treat back pain. Both patients were treated with antibiotics and eventually recovered, according to FDA documents cited by the committee.

When officials from the FDA and Massachusetts Board of Pharmacy visited NECC later in the month, Cadden said vials of the steroid returned by the hospital had tested negative for bacterial contamination. But when FDA scientists tested samples of the drug collected in New York they found bacterial contamination in four out of 14 vials sampled. It is not entirely clear whether FDA tested the same lot shipped to the Rochester hospital.

__ At a February 2003 meeting between state and federal officials, FDA staff emphasized “the potential for serious public consequences if NECC’s compounding practices, in particular those relating to sterile products, are not improved.” The agency issued a list of problems uncovered in its inspection to NECC, including a failure to verify if sterile drugs met safety standards.

But the agency decided to let Massachusetts officials take the lead in regulating the company, since pharmacies are typically regulated at the state level. It was decided that “the state would be in a better position to gain compliance or take regulatory action against NECC as necessary,” according to a summary of the meeting quoted by investigators.

The FDA recommended the state subject NECC to a consent agreement, which would require the company to pass certain quality tests to continue operating. But congressional investigators say Massachusetts Board of Pharmacy did not take any action until “well over a year later.”

__ In October 2004, the board sent a proposed consent agreement to Cadden, which would have included a formal reprimand and a three-year probationary period for the company’s registration. The case ended without disciplinary action in 2006, when NECC agreed to a less severe consent decree with the state.

Massachusetts officials indicated Tuesday they are still investigating why NECC escaped the more severe penalty.

“I will not be satisfied until we know the full story behind this decision,” the state’s interim health commissioner Lauren Smith said in a transcript of her prepared testimony released a day ahead of delivery. Smith is one of several witnesses scheduled to testify Wednesday, including FDA Commissioner Margaret Hamburg.

The committee will also hear from the widow of 78-year-old Eddie C. Lovelace, a longtime circuit court judge in southern Kentucky. Autopsy results confirmed Lovelace received fungus-contaminated steroid injections that led to his death Sept. 17.

Joyce Lovelace will urge lawmakers to work together on legislation to stop future outbreaks caused by compounded drugs, according to a draft of her testimony.

“We now know that New England Compounding Pharmacy, Inc. killed Eddie. I have lost my soulmate and life’s partner with whom I worked side by side, day after day for more than fifty years,” Lovelace states.

Barry Cadden is also scheduled to appear at the hearing, after lawmakers issued a subpoena to compel him to attend.

The NECC has been closed since early last month, and Massachusetts officials have taken steps to permanently revoke its license. The pharmacy has recalled all the products it makes, including 17,700 single-dose vials of a steroid that tested positive for the fungus tied to the outbreak.

Health News Headlines – Yahoo! News

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Congress' choice whether Petraeus testifies on Benghazi attack

Holly Petraeus and Gen. David Petraeus walk past a seated Paula Broadwell (rear right) at his confirmation hearing …The White House said Tuesday that it was "up to Congress" whether to call former CIA Director David Petraeus to testify about the Sept. 11 attack in Benghazi, Libya.

"Congress [makes] decisions about who is called to testify," press secretary Jay Carney told reporters at his daily briefing.

The Intelligence Committees of the Senate and House of Representatives had been set to hear from Petraeus about the attack on the American compound in separate closed-door hearings on Thursday. But aides to both panels indicated that the retired Army general would be replaced by Mike Morrell, the acting CIA director.

"The president is confident that Acting Director Morrell is fully informed and capable of representing the CIA in a hearing about the incidents in Benghazi," Carney said.

Still, key senators have made it clear that Petraeus, whose shocking resignation came after the public disclosure of an extramarital affair, will ultimately need to be heard. The attack claimed the lives of U.S. Ambassador Chris Stevens and three other Americans.

Senate Intelligence Committee Chairwoman Dianne Feinstein, a Democrat, told MSNBC on Monday that her panel "should go ahead with Mike Morell and the way it is now set up."

"But I also think that the community should know that this is not sufficient," she continued. "And I have no doubt now that we will need to talk with David Petraeus. And we will likely do that in closed session, but it will be done one way or the other."

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Canada seen needing to spell out rules for natural gas projects

CALGARY, Alberta (Reuters) – The fate of a handful of liquefied natural gas projects planned for Canada’s Pacific coast may depend on the Canadian government‘s willingness to spell out rules for foreign investment in the country’s energy sector, according to a study released on Thursday.

Apache Corp, Royal Dutch Shell Plc, Petronas, BG Group Plc and others are in the planning stages for LNG projects that would take gas from the rich shale fields of northeastern British Columbia and ship it to Asian buyers.

But the federal government’s decision last month to stall the C$ 5.2 billion ($ 5.2 billion) bid by Malaysia’s state-owned Petronas C$ 5.2 billion for Canada‘s Progress Energy Resources Corp could lessen the appetite of Asian buyers for Canadian LNG, energy consultants Wood Mackenzie said.

“Some potential off-takers of Canadian LNG like the idea … because it’s perceived as having low political risk, and another reason is because they see the potential for investment opportunities,” said Noel Tomnay, head of global gas at the consultancy.

“If there are going to be restrictions on how they access those opportunities, if acquisitions are closed to them, then clearly that would restrict the attractiveness of those opportunities. If would-be Asian investors thought that corporate acquisitions were an avenue that was not open to them then Canadian LNG would become less attractive.”

The Canadian government is looking to come up with rules governing corporate acquisitions by state-owned companies and has pushed off a decision on the Petronas bid as it considers whether to approve the $ 15.1 billion offer for Nexen Inc from China’s CNOOC Ltd.

Exporting LNG to Asia is seen as a way to boost returns for natural-gas producers tapping the Montney, Horn River and Liard Basin shale regions of northeastern British Columbia.

Though Wood Mackenzie estimates the fields contain as much as 280 trillion cubic feet of gas, they are far from Canada’s traditional U.S. export market, while growing supplies from American shale regions have cut into Canadian shipments.

Because the region lacks infrastructure, developing the resource will be expensive, requiring new pipelines and multibillion-dollar liquefaction.

Still Wood Mackenzie estimates that the cost of delivery into Asian markets for Canadian LNG would be in the range of $ 10 million to $ 12 per million British thermal units, similar to competing projects in the United States and East Africa.

($ 1 = $ 1.00 Canadian)

(Reporting by Scott Haggett; Editing by Leslie Adler)

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Political Polling After the End of the Phone

With over a third of U.S. households forgoing the land-line and people using their phones less and less for talking, the phone call is no longer the best way for pollsters to reach the people they need to speak with. With that changing trend, this election season polling places like Gallup worked cell-phone calls into its repertoire to get a better reflection of society, Gallup spokesperson Frank Newport told Wired‘s Mat Honan. And, logically, as more people replace landlines for cell phones, polling would increasingly throw cell-phones into the mix. But, it doesn’t look like that’s really the next frontier in polling. For one, it’s expensive. A 1996 Federal regulation requires that calls to cell phones be hand-dialed, rather than computer generated, which costs more money because employing people (rather than machines) takes dollars, notes Bits Blog’s Quentin Hardy. Plus, because of caller-ID, guilting cell phone users into taking a poll proves harder than haranguing an unsuspecting land-line answerer. (Of course, many land-line owners have caller-ID, too.) So, if the annoying, always disruptive at the worst time, pollster phone call is on the outs, then what does the future of political polling hold?

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Survey Monkey

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For real. The amateur-looking website conducted a series of polls throughout this election period, at times with better accuracy than the over-the-phone guys. In an explanatory post on the site, the company explains it had 96 percent accuracy with its methods. Over 60,000 people took one of the site’s surveys the day before election day alone, SurveyMonkey’s vice president, Philip Garland, told Hardy. 

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Though some have questioned the accuracy of the online poll because of its newness to the field. Nate Silver, whose words on all things polling we should now consider law, confirmed that many of the most accurate polling came from online surveys. “When people are asked questions by a person, they feel like they should make a choice,” Garland added. People are more candid on the Internet, which is not at all surprising. 

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Text Messages

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Though a new survey says that text messaging is on the decline, Gallup is already experimenting with it as a polling technique in Central and South America, notes Honan. Though it doesn’t sound that different than screening a phone call, text messages are a lot less invasive and they don’t require an answer right away. Also, increasingly, it is how people do much of their communicating. 

Emails, Unfortunately

Though that sounds logical since so many Americans are accessible by email, it turns out it is too hard to get a good sample using email, since many people have multiple email addresses, and it’s hard to account for that difference. Also, isn’t it just so easy to click delete without opening? However, that hasn’t stopped certain organizations from using it, as Bloomberg Businessweek‘s Peter Coy explains. Some firms use email lists that aren’t representative of the general population, he notes. 

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